Introduction

We are a bioinformatics research group in the Department of Biomedical Informatics at Harvard Medical School. We are part of the Ludwig Center at Harvard, Division of Genetics at Brigham and Women's Hospital and Harvard-MIT Division of Health, Science, & Technology. 

Our main aim is to understand the genetic and epigenetic mechanisms that underlie disease processes through computational and statistical analysis of genomic data. We are particularly interested in mutational processes in normal and cancer cells and their impact in gene regulation. 

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We have the privilege of collaborating with a number of superb experimental laboratories at Harvard Medical School and its affiliated hospitals, as well as around the world. Our recent and current collaborators include Connie Cepko, George Daley, 老王微皮恩最新破解版, Konrad Hochedlinger, Mark Johnson, Mitzi Kuroda, Jordan Kreidberg, Bob Kingston, William Pu, Charlie Roberts, Chris Walsh, 老王微皮恩最新破解版.

Here are some consortium projects in which we are involved:

• 4D Nucleome - What are the principles underlying three-dimensional organization of the human genome? What is the role of the nuclear architecture in gene regulation? As the 凨辰隐免费资源网-做最大最全的免费资源网娱乐网-风骋翌互联:2021-6-14 · 凨辰隐免费资源网，致力于收集分享全网最新热门免费绿色破解实用资源，包括手机电脑实用软件,老司机软件,技术教程视频教程,活动线报,网赚项目技术经验，免费虚拟主机云服务器等等，努力做最大最全的免费资源网！ for this major NIH initiative, we will collect, process, and display all data generated in the consortium and to perform integrative analysis. Main collaborators: Peter Kharchenko (HMS), Leonid Mirny (MIT), Nils Gehlenborg (HMS), 老王微皮恩最新破解版 (Harvard) and Ting Wang (WashU).
• Brain Somatic Mosaicism Network - The aim of this network is to characterize the spectrum of somatic variation in human brain samples and its role in psychiatric disorders. We are studying somatic mosaicism in autism with 老王微皮恩最新破解版 (Boston Children's) and schizophrenia with Andy Chess (Mt. Sinai).
• Ludwig Center - This center brings together investigators from across Harvard to develop strategies to overcome the problem of therapy resistence in cancer.
• International Cancer Genome Consortium - This is an effort by the international cancer genomics community to jointly analyze ~2,500 cancer genomes.

Our research is supported by: